The morbidity and mortality after solid organ transplantation leads to poor outcomes in the
long-term graft survival. There are many sources increasing bad outcomes within the post-transplant
period reducing the quality of recipient´s life, such as rejection episodes, opportunistic infections as
well as immunosuppression related morbidity. A complete understanding on the immune system responses
against the allo-graft remains unknown. Recently, some pro-inflammatory cytokines, such as
IFN-γ and IL-17, as well as IL-2, have been proposed as surrogate biomarkers able to predict the appearance
of clinical event episodes. In this review we summarize the latest findings regarding the immune
function monitoring in solid organ transplantation as well as the most common techniques
(ELISPOT, ELISA and Flow Cytometry) that have been widely used across different clinical laboratories.
Keywords: Immune function monitoring, predictive biomarkers, acute rejection, opportunistic infection, cytokine.
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