D Allele Frequency in Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme (ACE) Gene is Associated with Development of Breast Cancer Risk in Indian Women

Author(s): Shashank Kumar, Syed Rizwan Hussain, Mohammad Waseem, Farzana Mahdi, Cherry Bansal, Mohammad Kaleem Ahmad.

Journal Name: Current Proteomics

Volume 13 , Issue 4 , 2016

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Abstract:

Aims: Breast cancer is the second most common cancer in the world and, by far, the most frequent cancer among women. Scientific literature has hypothesized the association of ACE I/D polymorphism with breast cancer for several decades. Unfortunately the outcomes of studies are inconsistent. Thus the present study was designed to evaluate the association of ACE gene (I/D) polymorphism with breast cancer in Indian population.

Methods: Genotyping was performed by PCR (polymerase chain reaction), using genomic DNA extracted from peripheral blood of subjects, with (213 cases) or without (213 controls) breast cancer.

Findings: The distribution of ACE genotype frequencies i.e. II, DD and ID in patients was 43.19%, 16.43% and 40.38% respectively. In healthy control group II, DD and ID frequencies were 52.58%, 11.27% and 36.15% respectively. The frequencies of D and I alleles were 29.34% and 70.66% in the healthy subjects, while 36.62% and 63.38% among the patient group. Frequency of D allele was significantly different (p=0.0287) between control and case subjects.

Significance: The present study showed an association of D allele of ACE gene with increased genetic risk factor for breast cancer in Indian women. 0.2% increased disease risk was found in patients carrying D allele.

Keywords: Angiotensin converting enzyme (ACE), breast cancer, genotype, indian population, polymorphism.

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2016
Page: [297 - 304]
Pages: 8
DOI: 10.2174/1570164613666160902125913
Price: $58

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