Objective: To prepare sustained release micro-/nanospheres of Ketoprofen (KFN) loaded Eudragit
® RS100 with ethyl cellulose and polycaprolactone (PCL).
Method: The sustained release micro-/nanospheres of Ketoprofen (KFN) loaded Eudragit®
ethyl cellulose and polycaprolactone (PCL) were prepared by single emulsion [oil-in-water (o/w)] solvent
Results: The resultant micro-/nanospheres were evaluated for their size, surface morphology, encapsulation
efficiency and in vitro drug release. The prepared KFN loaded Eudragit®
RS100 with ethyl cellulose
micro-/nanospheres was showed encapsulation efficiency in the range from 59.81% to 96.14%
while KFN loaded PCL micro-/nanospheres showed 54.46% to 88.52%. The micro-/nanospheres were
found discrete and globular in shape. The absence of interaction between KFN and polymers were confirmed
by Fourier Transform Infrared spectroscopy (FTIR). The X-ray diffraction (XRPD) revealed the
dispersion of drug within micro-/nanospheres formulation. The in-vitro drug released study showed sustained
release drug profile over a period of 12 h.
Conclusion: These results could be helpful for finding the optimum formulation valuables for encapsulation
efficiency as well as drug released profile of sustained release micro-/nanospheres.