Pharmacological Functional MRI in Rodent Model

Author(s): Tomokazu Tsurugizawa* .

Journal Name: Current Psychopharmacology

Volume 6 , Issue 1 , 2017

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Graphical Abstract:


The pharmacological effects on the brain will occur widely in whole brain. Therefore, pharmacological functional MRI (fMRI) is a promising non-invasive tool to investigate the whole brain activation following pharmacological stimulation. The multimodal fMRI techniques, which reflect the vascular response (blood oxygenation level dependent fMRI), neuron/astrocyte activity (diffusion fMRI) and Ca2+ influx in excitatory neurons (manganese enhanced MRI), enable to observe the neuronal activation in rodent model. In the present study, the multimodal pharmacological fMRI method in rodents will be introduced.

Keywords: Functional MRI, rodent, anesthesia, BOLD, DfMRI, MEMRI, pharmacological fMRI.

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Article Details

Year: 2017
Page: [4 - 11]
Pages: 8
DOI: 10.2174/2211556005666160901150718
Price: $58

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