Therapeutic proteins are engineered proteins produced in the laboratory for pharmaceutical
use. With the advent of recombinant DNA technology, the proteins can be generated in specific host
cells under defined conditions. In the process of production of genetically engineered animals, the gene
of interest can be added at a single cell stage to produce a cloned animal from genetically engineered
cells. Several recombinant cytokines, clotting factors etc have been licensed and are currently being
utilized for the treatment of cancer, infectious diseases, hemophilia, anemia, multiple sclerosis, and
hepatitis B/C. Therapeutic proteins that are useful for human are successfully produced in poultry as
well as in livestock animals. However, the fastest growing class of therapeutic proteins are antibodies
especially monoclonal antibodies (mAb), the most important class of therapeutic protein with the potential
to generate significant revolution in terms of clinical success rate. Here, we review the most recent
clinical advances in the field of emerging and existing therapeutic proteins.
Keywords: Chimeric antibodies, clotting factors, cytokines, hormones, medicinal chemistry, therapeutic proteins.
Rights & PermissionsPrintExport