Dengue fever, a type of global and tropical infectious disease, and its prevention has become
a challenging issue worldwide. Antibody-dependent enhancement effects and the virus pathogenic
mechanism have not yet been fully elucidated, hindering the development of dengue fever prevention
and suitable drug treatment. There is currently no specific prevention and therapy in clinical
trials, however, in recent years, studies have focused on the pathogenesis and treatment of dengue.
Research focusing on dengue virus nonstructural protein in special drugs for the prevention and control
of dengue fever is a new progress leading to improved understanding regarding the prevention
and control of dengue fever and suitable drugs for the treatment. The main challenges regarding the
structure of dengue virus nonstructural protein and the drugs for antiviral therapy are summarized in
Keywords: Dengue virus, Non-structural protein, Structure, Function, Antiviral therapy.
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