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Current Drug Delivery

Editor-in-Chief

ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Research Article

Quercetin-Decorated Curcumin Liposome Design for Cancer Therapy: In-Vitro and In-Vivo Studies

Author(s): V. Ravichandiran, K. Masilamani, B. Senthilnathan, A. Maheshwaran, Tin Wui Wong and Partha Roy*

Volume 14, Issue 8, 2017

Page: [1053 - 1059] Pages: 7

DOI: 10.2174/1567201813666160829100453

Price: $65

Abstract

Background: Curcumin is a yellow polyphenolic chemopreventive agent isolated from the rhizomes of Curcuma longa. It is approved as Generally Regarded as Safe by US FDA. Nonetheless, its clinical success is limited due to its poor aqueous solubility, fast metabolism and short biological half-life attributes.

Objective: Quercetin-decorated liposomes of curcumin (QCunp) are perceived to be able to overcome these biopharmaceutical drawbacks.

Methods: Curcumin liposomes with/without quercetin were prepared by lipid hydration technique. The liposomes were characterized for their particle size, zeta potential, surface morphology, drug loading and release characteristics. The toxicity of the liposomes were evaluated in-vitro and their invivo efficacy were tested against Dalton's ascites lymphoma in mice.

Results: Liposomes designed showed particle size of 261.8 ± 2.1 nm with a negative zeta potential of -22.6±1.6 mV. Quercetin decorated liposomes were more effective in increasing the life span and body weight of lymphoma inflicted mice compared to those without quercetin. Similarly, the presence of quercetin also contributed to enhanced cytotoxicity of the liposomal formulation towards HT-29 cells and HCT-15 cells.

Conclusion: Newer liposomal design exhibited promising potential to emerge as alternative anticancer therapeutics.

Keywords: Curcumin, Dalton's ascites lymphoma, liposomes, quercetin, cancer, cytotoxicity.

Graphical Abstract

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