Design, Synthesis and Antidepressant and Anticonvulsant Effect of 1-Alkoxy-1H-Benzo[d]-1,2,3-Triazole Derivatives

Author(s): Yu Sun, Qing-Hao Jin, Yan Han, Di Yu, Qiu-Ping Dai, Zhou-Jun Zheng.

Journal Name: Letters in Drug Design & Discovery

Volume 14 , Issue 3 , 2017

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Abstract:

Background: 21 novel 1-alkoxy-1H-benzo[d]-1,2,3-triazole compounds were designed, prepared and evaluated for their antidepressant and anticonvulsant effects in mice.

Method: Compound 19 significantly decreased immobility time in the FST without altering the locomotor activity in the open field test, and exhibited higher levels of efficacy than the reference standard fluoxetine. Compound 19 significantly increased 5-HT, NE and 5-HIAA levels in mice brain, implying that the antidepressant activity might be mediated by these neurotransmitters. In the seizure test, compound 19 also showed better anticonvulsant activity against MES, whereas had not shown neurotoxicity (300 mg/kg).

Conclusion: Our data indicated that compound 19 could potentially be used as the antidepressant drug in patients with epilepsy.

Keywords: Benzo[d]-1, 2, 3-triazole, FST, neurotransmitters, MES, antidepressant.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2017
Page: [314 - 322]
Pages: 9
DOI: 10.2174/1570180813666160826113018
Price: $58

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