B-cell lymphomas represent a heterogeneous collection of more than
twenty-five different malignancies. Classification is often challenging as primarily
based upon, sometimes subjective, histopathological criteria and misdiagnosis can
result in inappropriate treatment decisions. MicroRNAs (miRNAs) hold great promise
as novel biomarkers (diagnostic, prognostic and predictive) of B-cell lymphoma
in addition to being potential therapeutic targets. The most promising of these miRNAs
more often than not play key regulatory roles in lymphopoiesis (development
of lymphocytes) when under physiological conditions, and in the pathology of lymphoid
malignancies when aberrantly expressed. In this review we consider the identity
and functional role of miRNAs in the most common forms of B-cell lymphomas,
their role in lymphopoiesis and their potential as biomarkers for these malignancies.
Keywords: Biomarker, blood, diffuse large B cell lymphoma, lymphoma, lymphomagenesis, microRNA.
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