Background: Prohibitin (PHB) is overtly conserved evolutionarily and ubiquitously expressed
protein with pleiotropic functions in diverse cellular compartments. However, regulation and
function of these proteins in different cells, tissues and in various diseases is different as evidenced by
expression of these proteins which is found to be reduced in heart diseases, kidney diseases, lung disease,
Crohn's disease and ulcerative colitis but this protein is highly expressed in diverse cancers. The
mechanism by which this protein acts at the molecular level in different subcellular localizations or in
different cells or tissues in different conditions (diseases or normal) has remained poorly understood.
There are several studies reported to understand and decipher PHB's role in diseases and/or cancers of
ovary, lung, stomach, thyroid, liver, blood, prostrate, gastric, esophagus, glioma, breast, bladder etc.
where PHB is shown to act through mechanisms by acting as oncogene, tumor suppressor, antioxidant,
antiapoptotic, in angiogenesis, autophagy etc.
Objective: This review specifically gives attention to the functional role and regulatory mechanism of
PHB proteins in cardiovascular health and diseases and its associated implications. Various molecular
pathways involved in PHB function and its regulation are analyzed.
Conclusion: PHB is rapidly emerging as a critical target molecule for cardiovascular signaling. Progress
in delineating CVD and mechanisms of PHB in diverse molecular pathways is essential for determining
when and how PHB targeted therapy might be feasible. In this regard, new therapies targeting
PHB may best be applied in the future together with molecular profiling of CVD for clinical stratification
of disease diagnosis and prognosis.