The Male Abnormal Gene Family 21 (Mab21) Members Regulate Eye Development

Author(s): Z.-X. Huang, J.-W. Xiang, L. Zhou, Q. Nie, L. Wang, Z.-G. Chen, X.-H. Hu, Y. Xiao, W.-J. Qing, Y.-F. Liu, Q. Sun, X.-C. Tang, F.-Y. Liu, Z.-W. Luo, W.-B. Liu, D. W.-C. Li.

Journal Name: Current Molecular Medicine

Volume 16 , Issue 7 , 2016

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Abstract:

The male abnormal gene family contains 3 members, named mab21l1, mab21l2 and mab21l3. Since their first discovery in C. elegans, homologues of mab21l1 and mab21l2 have been found in Drosophila, Zebrafish, Xenopus, chicken, mouse and human. A number of studies have revealed that mab21 gene family members, mab21l1 and mab21l2, play important roles in regulating eye development. Here, we review the functions of the mab genes in regulating ocular development.

Keywords: Mab21, eye development, Pax-6, Mab21L1, Mab21L2.

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Article Details

VOLUME: 16
ISSUE: 7
Year: 2016
Page: [660 - 667]
Pages: 8
DOI: 10.2174/1566524016666160824150729
Price: $58

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