The male abnormal gene family contains 3 members, named
mab21l1, mab21l2 and mab21l3. Since their first discovery in C. elegans,
homologues of mab21l1 and mab21l2 have been found in Drosophila,
Zebrafish, Xenopus, chicken, mouse and human. A number of studies have
revealed that mab21 gene family members, mab21l1 and mab21l2, play
important roles in regulating eye development. Here, we review the
functions of the mab genes in regulating ocular development.