Cardiovascular disease is the main cause of death in the developed countries. Dyslipidaemia
is one of the risk factors associated to cardiovascular disease and it is characterised by abnormal
amounts of lipids (i.e. cholesterol and fatty acids) and/or circulating lipoproteins in the blood. Oxidative
stress has been implicated in the pathogenesis of various illnesses including cardiovascular disease. In
this way, the potential therapeutic or preventive effects of antioxidant mediators have recently drawn
much attention. Coumarin (1,2-benzopyrone) is a natural phenolic compound found in many plants
such as citrus fruits, tomatoes, vegetables and green tea. Coumarin and derivates are proposed as lipid
lowering agents due to its broad pharmacological activities, mainly the implicated in vasodilator and
antioxidant effect. Several studies have evidenced a promising role of coumarin and several of its derivates
as lipid lowering agents. In the current work, the available reports related to the promising function
of these compounds are reviewed.
Keywords: Cardiovascular diseases, Phenolic acids, Cholesterol, Lipid metabolism.
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