In Vivo Measurement in Pigs of Wash-In Kinetics of Xenon at its Site of Action

Author(s): Gebhard Froeba, Oliver Adolph.

Journal Name: Current Clinical Pharmacology

Volume 11 , Issue 4 , 2016

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Abstract:

Background: Xenon (Xe) in many respects is an ideal anaesthetic agent. Its blood/gas partition coefficient is lower than that of any other anaesthetic, enabling rapid induction of and emergence from anaesthesia. While the whole body kinetics during wash-in of inhalational anaesthesia is well known, data describing the pharmacokinetics of xenon in the cerebral compartment at the site of action are still largely missing.

Methods: In order to illuminate xenon’s cerebral pharmacokinetics, we anaesthetised five pigs and measured arterial, mixed- and sagittal sinus-venous blood, as well as end-expiratory gas concentrations of xenon by gas chromatography-mass spectrometry (GCMS) up to 30 minutes after starting the anaesthetic gas mixture.

Results: Despite xenon’s fast onset of effect the half-time for equilibration between xenon concentration in arterial blood and at the site of action is measured to be 1.49 ± 0.04 minutes versus 3.91 ± 0.1 minutes. Successful loading of xenon in the brain during inhalational anesthesia was accomplished after approximately 15 minutes although the end-expiratory xenon concentration reached a plateau after 7 minutes. Thus cerebral xenon uptake rate is only moderate, xenon's fast onset of action being largely due to its extremely fast alveolar uptake.

Conclusions: To ensure safety and precise control during anaesthesia we need a profound knowledge about to what extent the measured end-tidal concentrations reflect the drug concentrations in the target tissue. The results of this study expand our knowledge about the temporal characteristics of xenon´s pharmacokinetics at its site of action and provide the basis for appropriate clinical protocols and experimental designs of future studies.

Keywords: Xenon, pharmacokinetics, cerebral compartment, inhalational anaesthesia, half-time of equilibration, pigs.

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Article Details

VOLUME: 11
ISSUE: 4
Year: 2016
Page: [224 - 229]
Pages: 6
DOI: 10.2174/1574884711666160823130535
Price: $58

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