Background: The safety of zopiclone and other Z-drug use has been questioned in
many regards. Past issues of side effects, tolerance, abuse, addition, and inappropriate uses
have all deserved attention.
Objective: In this paper, the issue of zopiclone safety is again reviewed for information newly
arising over the last decade.
Method: Information databases were scanned for ‘zopiclone’, and all relevant literature was
Results: Zopiclone continues to be a very frequently consumed sedative-hypnotic. It is often
found in the blood of those with drug abuse, self-harm, overdose, and road accidents. The
drug is flourishing as a medication for the elderly, and numerous adverse consequences, including
injury, have been associated with it. Zopiclone impairs driving ability, and methods
to determine such impairment among active drivers are needed.
Conclusion: We have previously suggested that zopiclone prescription and use should have
the same concerns as those for benzodiazepine pharmacotherapy. There is evidently no need
to change such a stance.