The development of efficient routes to pyrazines and their ring fused analogues is an attractive area of
research since these compounds are now widely recognized as important N-heterocycles for their potential use in
medicinal and agricultural scientific fields. In this review, we describe the most representative and interesting
methods for the synthesis of pyrazines from N-propargylamines. Mechanistic aspects of the reactions are considered
and discussed in detail.
Keywords: Pyrazines, ring fused pyrazines, N-propargylamines, 6-exo-dig cyclization, 1, 3-dipolar cycloaddition.
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