New Page to Access Pyrazines and their Ring Fused Analogues: Synthesis from N-Propargylamines

Author(s): Esmail Vessally*, Akram Hosseinian, Ladan Edjlali, Ahmadreza Bekhradnia*, Mehdi D. Esrafili.

Journal Name: Current Organic Synthesis

Volume 14 , Issue 4 , 2017

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Abstract:

The development of efficient routes to pyrazines and their ring fused analogues is an attractive area of research since these compounds are now widely recognized as important N-heterocycles for their potential use in medicinal and agricultural scientific fields. In this review, we describe the most representative and interesting methods for the synthesis of pyrazines from N-propargylamines. Mechanistic aspects of the reactions are considered and discussed in detail.

Keywords: Pyrazines, ring fused pyrazines, N-propargylamines, 6-exo-dig cyclization, 1, 3-dipolar cycloaddition.

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Article Details

VOLUME: 14
ISSUE: 4
Year: 2017
Page: [557 - 567]
Pages: 11
DOI: 10.2174/1570179413666160818144816
Price: $58

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