Oral mucosa is a mucous membrane lining the oral cavity. Its main function is to protect the
deeper structures against the external factors; thermal, chemical, mechanical and biological stimuli. Apart
from that, it also plays a significant role during mastication, deglutition and speech. Some oral diseases or
injuries to oral mucosa lead to impairment of the oral functions and aesthetics which eventually result in
permanent defect of oral mucosa. In order to overcome this defect, different approaches for the development
of reconstructed oral mucosa models have been employed including skin/autologous grafts, guided
tissue replacement, vestibuloplasty etc. However, the finding of an acceptable source for the transplantations
or autologous grafts seems a bit challenging. To overcome this problem, the development of oral
mucosa using tissue engineering approach has been widely studied involving various cell lines from different
sources. This paper aims to highlight various cell sources used in the development of tissueengineered
oral mucosa models based on articles retrieved from PubMed and MEDLINE databases using
the search terms “oral mucosa tissue engineering”, regardless of time when published.
Keywords: Oral mucosa model, tissue engineering, dental stem cells, cell sources, three-dimensional, co-culture.
Rights & PermissionsPrintExport