Comparative Genomics and Discovery of Novel Cellular Targets for the Development of New Therapeutics Towards Vibrio cholerae, the Causative Agent of Cholera Disease

Author(s): Mun Mun Mukherjee, Sanath Kumar, Ugina Shrestha, Indrika Ranaweera, Ranjana KC, Prathusha Kakarla, T. Mark Willmon, Alberto J. Hernandez, Guixin He, Chanmary Lau, Sharla R. Barr, Manuel F. Varela.

Journal Name: Anti-Infective Agents

Volume 14 , Issue 2 , 2016

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Abstract:

Vibrio cholerae is a Gram-negative bacterium and causative agent of cho-lera, which is a severe gastrointestinal disease and a global public health concern. Repletion and antimicrobial drug therapies are necessary for efficacious treatment of severe cases of cholera. In situations where proper sanitation and repletion therapy are unavailable and multidrug resistant V. cholerae variants are present, alternative means of therapy are indicated. Towards this, comparative genomic analyses bet-ween virulent versus non-virulent serotypes of V. cholerae have been useful in iden-tifying new cellular targets for the development of new chemotherapies for cholera. This review article explores these new avenues for cholera treatments and sum-marizes these novel putative drug targets.

Keywords: Vibrio cholerae, cholera, antimicrobial resistance, drug targets.

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Article Details

VOLUME: 14
ISSUE: 2
Year: 2016
Page: [88 - 99]
Pages: 12
DOI: 10.2174/2211352514666160816151125
Price: $58

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