Vibrio cholerae is a Gram-negative bacterium and causative agent of cho-lera, which is a
severe gastrointestinal disease and a global public health concern. Repletion and antimicrobial drug
therapies are necessary for efficacious treatment of severe cases of cholera. In situations where proper
sanitation and repletion therapy are unavailable and multidrug resistant V. cholerae variants are present,
alternative means of therapy are indicated. Towards this, comparative genomic analyses bet-ween
virulent versus non-virulent serotypes of V. cholerae have been useful in iden-tifying new cellular
targets for the development of new chemotherapies for cholera. This review article explores these new
avenues for cholera treatments and sum-marizes these novel putative drug targets.
Keywords: Vibrio cholerae, cholera, antimicrobial resistance, drug targets.
Rights & PermissionsPrintExport