Objective: This study was accomplished to evaluate the in vitro antioxidant activity, in vivo
antipyretic and the anti-inflammatory activities of the n-butanol extract of roots and aerial parts of Algerian
Eryngium campestre L.
Materials and Methods: The antioxidant properties were tested using DPPH radical scavenging and β-
Carotene linoleic acid of various extracts from roots and aerial parts of E. campestre L., total phenolic
and flavonoid contents were also determined. Furthermore, the anti-inflammatory and antipyretic activities
of the n-butanol extracts were investigated on female wistar rats at the dose levels of 250 and 500
mg/kg body weight, using the egg albumin induced oedema and brewer’s yeast induced pyrexia method
Results: n-butanol extract of aerial parts had considerably higher antiradical activity with IC50 value of
16.140 µg/ml, and a good anti-inflammatory activity comparable to the standard drug diclofenac. Also,
the n-butanol extract of roots possessed a better antipyretic effect (at both dose 250 mg/kg and 500
mg/kg) compared to the n-butanol extract of aerial parts.
Conclusion: These results suggested that Eryngium campestre L. could be used to treat various