Investigation of In Vitro Antioxidant Activity and In Vivo Antipyretic and Anti-Inflammatory Activities of Algerian Eryngium campestre L. | BenthamScience


Investigation of In Vitro Antioxidant Activity and In Vivo Antipyretic and Anti-Inflammatory Activities of Algerian Eryngium campestre L.

Author(s): Soumia Bouzidi, Naima Benkiki, Messaoud Hachemi, Hamada Haba*.

Journal Name: Current Bioactive Compounds

Volume 13 , Issue 4 , 2017

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Abstract:

Objective: This study was accomplished to evaluate the in vitro antioxidant activity, in vivo antipyretic and the anti-inflammatory activities of the n-butanol extract of roots and aerial parts of Algerian Eryngium campestre L.

Materials and Methods: The antioxidant properties were tested using DPPH radical scavenging and β- Carotene linoleic acid of various extracts from roots and aerial parts of E. campestre L., total phenolic and flavonoid contents were also determined. Furthermore, the anti-inflammatory and antipyretic activities of the n-butanol extracts were investigated on female wistar rats at the dose levels of 250 and 500 mg/kg body weight, using the egg albumin induced oedema and brewer’s yeast induced pyrexia method respectively.

Results: n-butanol extract of aerial parts had considerably higher antiradical activity with IC50 value of 16.140 µg/ml, and a good anti-inflammatory activity comparable to the standard drug diclofenac. Also, the n-butanol extract of roots possessed a better antipyretic effect (at both dose 250 mg/kg and 500 mg/kg) compared to the n-butanol extract of aerial parts.

Conclusion: These results suggested that Eryngium campestre L. could be used to treat various inflammatory diseases.

Keywords: Eryngium campestre, inflammation, pyrexia, antipyretic activity, anti-inflammatory activity, apiaceae, antioxidant activity.

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2017
Page: [340 - 346]
Pages: 7
DOI: 10.2174/1573407212666160815124204
Price: $58

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