Close to 1% of the world population suffer from schizophrenia.
Current medications for this chronic mental disorder have greatly improved
treatment over the last half century or more, but, the newer atypical antipsychotics
have proven to be disappointing, and enormous challenges remain.
The negative symptoms and cognitive dysfunction in schizophrenia which
greatly affect overall morbidity call for better treatments. Nitric oxide (NO),
an intra- and inter-cellular messenger in the brain, is involved in the pathogenesis
of schizophrenia, so excessive NO production might contribute to the
pathology. This implies that it might be useful to reduce nitrergic activity, so
molecules aiming to decrease NO production such as NO synthase (NOS)
inhibitors might be candidates. Here, I critically review advances in research on these emerging
molecules which hold promise although a note of caution is required on account of their
potential neurotoxicity and narrow therapeutic window.