Background: More than 90% of cancer deaths are caused by
cancer metastasis. Cancer metastatic therapy is a top priority topic.
Objective: New therapeutics against cancer metastasis is to be discovered.
Methods: In the past pathogenesis study, a therapeutic dilemma has been
discovered from literatures of epithelial-mesenchymal cell interchange in
late-staged cancer patients—opposite tumor pathogenesis routes between
primary and metastatic tumors.
Results: Possible options for overcoming this dilemma are enlisted from
different therapeutic attempts (such as novel drug target (cancer biomarkers)
discovery, antimetastatic drug developments, biotherapies, drug combinations, cancer therapeutics
according to metastatic cascades, different types of personalized medicine paradigms and so on).
Conclusions: These therapeutic options might change the landscape of cancer treatments and
managements in clinics forever.