TREM2 p.H157Y Variant and the Risk of Alzheimer’s Disease: A Meta-Analysis Involving 14,510 Subjects

Author(s): Teng Jiang, Jian-Kang Hou, Qing Gao, Jin-Tai Yu, Jun-Shan Zhou, Hong-Dong Zhao, Ying-Dong Zhang.

Journal Name:Current Neurovascular Research

Volume 13 , Issue 4 , 2016

Abstract:

We recently revealed that p.H157Y (rs2234255), a rare coding variant of triggering receptor expressed on myeloid cells 2 gene (TREM2), was associated with Alzheimer’s disease (AD) susceptibility in Han Chinese. Contrastingly, although p.H157Y was previously identified in both AD cases and controls by several sequencing studies, no association of this variant with disease susceptibility was reported. To gain a credible conclusion on the association between p.H157Y and AD risk, a meta-analysis involving 7,102 cases and 7,408 controls was conducted. Our results indicated that p.H157Y was associated with an increased risk of AD (OR=3.65, 95% CI: 1.61-8.28; P=0.002), further establishing TREM2 as an important susceptibility gene for this disease.

Keywords: TREM2, Alzheimer’s disease, meta-analysis, p, H157Y, rs2234255, Variant.

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2016
Page: [318 - 320]
Pages: 3
DOI: 10.2174/1567202613666160808095530
Price: $58