Active pharmaceutical ingredients (APIs) can exist in different polymorphic forms
as well as in amorphous state. Polymorphic and amorphous forms of APIs can differ in physicochemical
properties which in turn can significantly influence their therapeutic safety and
effectiveness of the treatment. This review focuses on benefits and limitations of polymorphic
and amorphous forms of APIs used in preformulation and formulation studies. Authors
present their work on safety precautions for the use of polymorphic and amorphous forms of
APIs, analytical techniques used for their identification as well as methods of their preparation
especially in regard to limitations of labile APIs.
Keywords: Polymorphs, amorphous form, active pharmaceutical ingredients, solubility, preparation of polymorphic and amorphous forms.
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