EGFR and EML4-ALK Updated Therapies in Non-Small Cell Lung Cancer

Author(s): Ramon Andrade De Mello* , Davi J. J. Liu , Pedro N. Aguiar , Hakaru Tadokoro .

Journal Name: Recent Patents on Anti-Cancer Drug Discovery

Volume 11 , Issue 4 , 2016

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Abstract:

Background: Non-small cell lung cancer is the leading cancer-related cause of death.

Objective: We review the latest therapies for NSCLC with EGFR and ELM4-ALK mutations as well as the most relevant studies and promising patents.

Method: A literature search of PubMed database was carried out to identify recent Clinical Trials using EGFR therapies and novel patents involving diagnosis and therapies on NSCLC. We conducted a search to find new therapy strategies, new biomarkers, and selected five patents we find relevant.

Results: Over the last few years, identification of cancer harboring epidermal growth factor receptor mutations (EGFR) or chromosomal rearrangements of anaplastic lymphoma kinase (ALK) led to new ways in classifying and treating NSCLC. On the other hand, acquired resistance are a constantly challenge in the management of patients with these mutations and new drugs options are in development to improve and amplify treatment strategies.

Conclusions: Currently, EGFR TKIs (e.g.: erlotinib, gefitinib, osimertinib) and ALK inhibitors (crizotinib, ceritinib, alectinib) provided a new face for advanced NSCLC outcomes. To understand the disease molecular profile is mandatory to define the best approach for each patient.

Keywords: Afatinib, EGFR, ELM4-ALK, erlotinib, geftinib, non-small cell lung cancer, osimertinib, patent.

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Article Details

VOLUME: 11
ISSUE: 4
Year: 2016
Page: [393 - 400]
Pages: 8
DOI: 10.2174/1574892811666160803090944
Price: $58

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