Title:Possible Anticancer Mechanisms of Some Costus speciosus Active Ingredients Concerning Drug Discovery
VOLUME: 13 ISSUE: 3
Author(s):Ali H. El-Far, Faried A. Badria and Hazem M. Shaheen
Affiliation:Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, El-Beheira, Egypt.
Keywords:Costus speciosus, anticancer mechanisms, future vision.
Abstract:Costus speciosus is native to South East Asia, especially found in India, Srilanka, Indonesia and Malaysia. C. speciosus have numerous therapeutic potentials against a wide variety of complains. The therapeutic properties of C. speciosus are attributed to the presence of various ingredients such as alkaloids, flavonoids, glycosides, phenols, saponins, sterols and sesquiterpenes. This
review presented the past, present, and the future status of C.
speciosus active ingredients to propose a future use as a potential
anticancer agent. All possible up-regulation of cellular apoptotic
molecules as p53, p21, p27, caspases, reactive oxygen species (ROS) generation and
others attribute to the anticancer activity of C. speciosus along the down-regulation
of anti-apoptotic agents such as Akt, Bcl2, NFKB, STAT3, JAK, MMPs, actin,
surviving and vimentin. Eventually, we recommend further investigation of different
C. speciosus extracts, using some active ingredients and evaluate the anticancer
effect of these chemicals against different cancers.
