Multicomponent Synthesis of Novel Class of Isatin and 5-isatinyli-denerhodanine Based Diaminofuran Derivatives

Author(s): Robabeh Baharfar, Somayeh Rassi.

Journal Name: Letters in Organic Chemistry

Volume 13 , Issue 6 , 2016

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Abstract:

A simple and efficient method has been developed for the synthesis of a new collection of isatin and 5-isatinylidenerhodanine derivatives carrying furan group, from N-(carboxymethyl)isatin through a multi-component reaction is explained. The reactive 1:1 intermediate formed from the reaction of isocyanides and dialkyl acetylenedicarboxylates was trapped at reflux temperature using N-(carboxymethyl)isatin derivatives to produce poly functionalized furan rings in good yields.

Keywords: 2, 5-diaminofurans, N-(carboxymethyl)isatin, isocynides, dialkyl acetylenedicarboxylates, rhodanine..

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2016
Page: [393 - 399]
Pages: 7
DOI: 10.2174/1570178613666160802145006
Price: $58

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