Malignant melanoma is an aggressive, therapy-resistant malignancy of melanocytes.
Although there is an increase in the worldwide incidences of melanoma, the recent data indicates that
rates are declining among those younger than 50 years of age. We present the case of a 50-year-old
Hispanic gentleman with metastatic malignant pleural melanoma, with tumor cells strongly positive for
Melan-A, HMB-45, and S-100. Pleural metastatic melanoma represents a rare event that has been
described in a small number of patients and they are found to be associated with reduced median overall
survival. Massive pleural effusion is also an unusual presentation and has been associated to impaired
lymphatic drainage due to infiltrated mediastinal lymph nodes.
Melanoma can emerge in sun-shielded
areas. Besides ultraviolet radiation, xenobiotics such as drugs and carcinogenic environmental toxins
filtered and bound to melanin, along with viruses are etiological candidates. Only a small number of
pleural metastatic melanoma cases have been reported and they are found to be associated with reduced
median overall survival.
Keywords: Cancer, lung cancer, melanoma, metastasis, pleura, thoracoscopy.
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