Allele Frequencies of CYP2D6, CYP3A5 and DPYD Genes Polymorphisms in the Healthy Yakut Population

Author(s): Filipp F. Vasilyev, Diana A. Danilova, Vladimir S. Kaimonov, Yana V. Chertovskih, Nadezda R. Maksimova.

Journal Name: Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics)

Volume 14 , Issue 1 , 2016

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Abstract:

Background: It is known that the distribution of polymorphism frequencies can vary greatly between different ethnic groups, resulting in variable percentages of poor, intermediate or extensive metabolizers in a given population.

Objective: This study was carried out to estimate the genotype frequencies of common variants in the CYP2D6, CYP3A5 and DPYD genes in the Yakut population from North-Eastern Siberia. To compare the allelic distribution found with the frequencies reported for other ethnic groups.

Method: Genotyping was carried out by real-time polymerase-chain reaction in a total of 100 healthy unrelated Yakut subjects (CYP2D6 c.100C>T, CYP3A5 g.6986G>A, DPYD c.1905+1G>A, DPYD c.1679T>G, DPYD c.2846T>A).

Results: The allele frequencies for CYP3A5*3 and DPYD*13 in Yakuts were 0.08 and 0.01, respectively. No DPYD*2A and DPYD c.2846A alleles were detected.

Conclusion: Our data on the distribution of frequencies of genotypes and alleles of polymorphisms of CYP2D6, CYP3A5 and DPYD genes in the Yakut population as a whole are more characteristic of the European populations.

Keywords: Allele frequency, genotyping, personalize medicine, pharmacogenetics, polymorphism, Yakuts.

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Article Details

VOLUME: 14
ISSUE: 1
Year: 2016
Page: [50 - 55]
Pages: 6
DOI: 10.2174/1875692114666160801151257

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