An efficient process for the large-scale synthesis of 4-methylnicotinic
acid is developed. The synthetic route utilized 2,6-dichloro-4-methylnicotinonitrile
as the starting material, which was commercially available. The key step in the sequence
was the reductive dechlorination in the presence of zinc and ammonia to
provide an intermediate which was hydrolyzed to the described acid. The reaction
parameters optimization and improvement of purification are also presented. This
approach, suitable for batch processing, is of interest basically to research laboratories
and also to suppliers in the research and fine chemicals market.
Keywords: 4-Methylnicotinic acid, dechlorination, synthesis.
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