Active pharmaceutical ingredients (APIs) can exist in various types of crystalline
forms including polymorphs and cocrystals. These multiple crystalline forms of APIs have
district physical and physicochemical characteristics. Vibrational spectroscopic techniques
used in solid-state pharmaceutical analysis include mid-infrared, Raman and terahertz
spectroscopy. In this review, we will focus on the recent vibrational spectroscopic investigation
on the polymorphism and cocrystallization of APIs in pharmaceutical fields. The
distinctive spectral and structural information of pharmaceutical polymorphs and cocrystals
could be obtained based on these vibrational spectroscopic techniques.
Keywords: Polymorphism, cocrystallization, vibrational spectroscopy, mid-infrared spectroscopy, Raman spectroscopy, terahertz timedomain
spectroscopy, active pharmaceutical ingredients.
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