Background: Acute pancreatitis (AP) is an inflammation process that
can affect the systemic inflammatory response syndrome, mainly in obese individuals.
The passion fruit peel flour (PFPF) is rich in fibers that help to reduce
cholesterol and blood glucose levels.
Methods: In this study, AP was induced by 5% sodium taurocholate inoculation
(biliopancreatic duct). The prognosis was evaluated after treatment with PFPF in
obese rats overfed during lactation. PFPF (40 mg/kg b.w.) was administered by
oral gavage five h after AP induction or sham surgery. Wistar rats were divided
into 6 groups: control; sham (CSP), AP (CP) and AP treated with PFPF (40mg)
(CP40); obese, sham (OSP), AP (OP), and AP treated with PFPF (40mg) (OP40).
Results: The results demonstrated a significant reduction of blood glucose and triglyceride concentrations
after PFPF treatment, compared to AP groups. PFPF treated groups also had lower concentrations
of IL-6, and an increased concentration of IL-10 in the OP40 group.
Conclusion: In conclusion, PFPF delays the absorption of simple carbohydrates, due to being rich in
pectin (in gel form). This improved glycemic control after AP induction. This may be useful in improving
the inflammatory response during acute pancreatitis.