Metabolic Features Across the Female Life Span in Women with PCOS

Author(s): Teresa Sir-Petermann , Bárbara Echiburú , Nicolás Crisosto , Manuel Maliqueo , Francisco Pérez Bravo .

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 36 , 2016

Abstract:

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine metabolic disorder and is presently considered a family pathology. It is associated with obesity, insulin resistance and metabolic syndrome. Racial, ethnic and environmental factors may be important in determining the clinical manifestations of this syndrome. Polycystic ovary syndrome is an exclusion diagnosis and, therefore, should be distinguished from the physiological changes typical for the age and from other hyperandrogenic disorders. Early diagnosis is important since this syndrome is associated with reproductive, oncologic and metabolic risks. Interestingly, the clinical features of this disorder may change throughout the lifespan of a PCOS woman, starting from adolescence to postmenopausal age. During the first decades of life the main features are in the reproductive area, while later in life metabolic abnormalities are more evident. While the assessment of insulin resistance is not part of the diagnosis of PCOS, it has been demonstrated that this metabolic component appears early in life and persists over time. Moreover during puberty and pregnancy, insulin resistance is exacerbated. Pregnancy represents an important stage, as the offspring of these patients may be reprogrammed and inherit some of the metabolic and reproductive features of their mothers. In the present review, we will focus on several metabolic aspects of the PCOS condition at different stages of life in a Chilean population.

Keywords: Polycystic ovary syndrome, insulin resistance, metabolic syndrome, pro-inflammatory factors, gestational diabetes, small/large for gestational age, PCOS offspring, long term complications.

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Article Details

VOLUME: 22
ISSUE: 36
Year: 2016
Page: [5515 - 5525]
Pages: 11
DOI: 10.2174/1381612822666160722100534
Price: $58

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