Plasmatic transthyretin may be regarded as a suitable candidate biomarker
for the onset, severity, and progression of Alzheimer disease. The aim of the present
experimental work was to evaluate the effect of red wine polyphenols (RWPs) on the
expression of transthyretin in murine choroid plexus. In contrast to what generally
reported in literature for polyphenols, our experimental results indicated a correlation
between RWPs assumption and a decrease of transthyretin expression, with a
non-dose dependent trend. The present study would point out the attention on the
possible pro-oxidant effects of red wine polyphenols at certain doses, although further
in vitro, in vivo, and clinical experiments must be performed in order to clarify
the mechanisms of action at the base of observed results.
Keywords: Murine model, neurodegeneration, red wine polyphenols, transthyretin.
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