Background: There is still speculative data regarding the role of spinal
dopaminergic neurotransmission in restless leg syndrome (RLS).
Methods: We evaluated the therapeutic role of pramipexole in a patient with cervical
disc prolapsus who exceptionally presented with neck restlessness.
Results: We have found that pramipexole leads to a significant improvement in
restlessness symptoms in the neck region.
Discussion: The therapeutic role of pramipexole may not only suggest secondary
deficits due to spinal pathologies but also indicate that specialized spinal dopaminergic
neurons may play an important role in the pathogenesis of region specific restlessness