Quinolones in the Search for New Anticancer Agents
Pedro Netto Batalha,
Maria Cecília Bastos Vieira de Souza,
David Cruz Cruz,
Fernanda da Costa Santos Boechat.
Quinolones have a large bio-dynamicity. Although they are well known as antibacterials,
another important activity has been investigated – quinolones are able to inhibit
cancer cell proliferation. In view of the great versatility associated with the synthesis of
quinolones, many researchers have spent time and resources on the development of new
structurally diversified quinolone derivatives with the purpose of finding new possibilities
for cancer treatment. In this review some of the most recent advances in the search for new
quinolone anticancer agents are highlighted, with focus on naturally occurring substances,
bioactive metal complexes, molecular hybrids, photosensitizers and heterocycle condensed
Keywords: Quinolones, cancer, topoisomerase, complexes, anticancer activity, photochemistry, natural products.
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