The reaction of 1-heteroaryl-3-(tetrazolo[1,5-a]quinolin-4-yl)prop-2-en-1-ones with hydrazine
hydrate in either ethanol or acetic acid furnished pyrazoline and N-acetylpyrazoline, respectively.
N-phenylpyrazolines and pyrazoline-N-carbothioamides were synthesized, in good yields,
from reaction of chalcons with phenylhydrazine and thiosemicarbazide, respectively. On the other
hand, a series of 2-pyrazolin-1-ylthiazoles have been synthesized via cyclization of pyrazoline-Ncarbothioamides
with different -haloketones such as phenacyl bromides, 3-bromoacetylcoumarin,
hydrazonoyl chlorides, and -chloroacetic acid. The structures of the newly synthesized compounds
have been confirmed by spectral analyses also the in vitro antimicrobial activities were studied.
Keywords: Tetrazolo[1, 5-a]quinoline-4-carbaldehyde, chalcones, pyrazolines, pyrazolinylthiazoles, antimicrobial activity,
structure-activity relationship (SAR).
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