Synthesis and Antimicrobial Evaluation of New Pyrazoline and Pyrazolinyl Thiazole Derivatives Bearing Tetrazolo[1,5-a]quinoline Moiety

Title:Synthesis and Antimicrobial Evaluation of New Pyrazoline and Pyrazolinyl Thiazole Derivatives Bearing Tetrazolo[1,5-a]quinoline Moiety

Volume: 13 Issue: 9

Author(s): Ibrahim A. M. Radini, Rizk E. Khidre and Emad M. El-Telbani

Affiliation:

Keywords: Tetrazolo[1, 5-a]quinoline-4-carbaldehyde, chalcones, pyrazolines, pyrazolinylthiazoles, antimicrobial activity, structure-activity relationship (SAR).

Abstract: The reaction of 1-heteroaryl-3-(tetrazolo[1,5-a]quinolin-4-yl)prop-2-en-1-ones with hydrazine hydrate in either ethanol or acetic acid furnished pyrazoline and N-acetylpyrazoline, respectively. N-phenylpyrazolines and pyrazoline-N-carbothioamides were synthesized, in good yields, from reaction of chalcons with phenylhydrazine and thiosemicarbazide, respectively. On the other hand, a series of 2-pyrazolin-1-ylthiazoles have been synthesized via cyclization of pyrazoline-Ncarbothioamides with different -haloketones such as phenacyl bromides, 3-bromoacetylcoumarin, hydrazonoyl chlorides, and -chloroacetic acid. The structures of the newly synthesized compounds have been confirmed by spectral analyses also the in vitro antimicrobial activities were studied.

Cite this article as:

Radini A. M. Ibrahim, Khidre E. Rizk and El-Telbani M. Emad, Synthesis and Antimicrobial Evaluation of New Pyrazoline and Pyrazolinyl Thiazole Derivatives Bearing Tetrazolo[1,5-a]quinoline Moiety, Letters in Drug Design & Discovery 2016; 13 (9) . https://dx.doi.org/10.2174/1570180813666160712234454