Energy Remodeling, Mitochondrial Disorder and Heart Failure

Author(s): Peng Wang, Lei Xu, Aijun Sun.

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 31 , 2016

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Abstract:

Heart failure (HF) is a major global problem in public health with no curative treatment currently available. Energy remodeling is one of the features in HF, preceding cardiac structure remodeling. As an important energy organelle, mitochondrion plays critical roles in the progress of HF. This review focuses on the potential mechanisms linking mitochondrial functions and energy remodeling in HF including the energy starvation theory and energy substrate metabolism. It also highlights the potentials of novel drugs targeting HF energy metabolism.

Keywords: Energy metabolism, mitochondrial disorder, heart failure.

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Article Details

VOLUME: 22
ISSUE: 31
Year: 2016
Page: [4823 - 4829]
Pages: 7
DOI: 10.2174/1381612822666160708224330
Price: $58

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