Heart failure (HF) is a major global problem in public health with no curative
treatment currently available. Energy remodeling is one of the features in HF, preceding
cardiac structure remodeling. As an important energy organelle, mitochondrion plays critical
roles in the progress of HF. This review focuses on the potential mechanisms linking mitochondrial
functions and energy remodeling in HF including the energy starvation theory and
energy substrate metabolism. It also highlights the potentials of novel drugs targeting HF
Keywords: Energy metabolism, mitochondrial disorder, heart failure.
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