Stem Cell Regulatory Mechanisms During Wound Healing and Cancer
Pp. 121Chapter-142 (22)
Ahmed RN Ibrahim, Deshna Majmudar, Safia Gilani, Jesse Garcia Castillo and Ahmed El-Hashash
Stem cells are known to have a paramount function in tissue regeneration
and also the proliferation of cancer, and the ability that stem cells have to self renew
allows them to differentiate and to regenerate injured tissues. More importantly, this
capacity to self renew allows cancer stem cells to proliferate and promote cancer.
Mesenchymal stem cells are multipotent cells that have the ability to differentiate into
various cell types including; adipocytes, osteoblasts, and chondrocytes. These cells are
known to regulate the healing of injuries and wounds and to activate cancer growth by
secreting bioactive factors through paracrine signaling. Through scientific research,
there is evidence that tissue specific and cancer stem cells also affect their surroundings
through paracrine mechanisms, which would permit stem cells to facilitate wound
recuperation and tumor proliferation, respectively. Because of this important
connection, further investigation of the paracrine mechanisms by stem cells would
ameliorate cancer treatment and cast light on the mechanisms of tissue regeneration.
Cancer, Stem Cells, Tissue Injury, Wound Healing.
Developmental Biology, Regenerative Medicine and Stem Cell Program, Saban Research Institute, Children`s Hospital Los Angeles, 4661 Sunset Boulevard MS 35, Los Angeles, California 90027, USA.