Developmental and Stem Cell Biology in Health and Disease

Research into stem cells started in the 1960s with experiments on spleen cultures. Evans and Kaufman made a breakthrough in mouse embryo culturing and embryonic stem cell extraction in 1981, followed ...
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Stem Cell Regulatory Mechanisms During Wound Healing and Cancer

Pp. 121Chapter-142 (22)

Ahmed RN Ibrahim, Deshna Majmudar, Safia Gilani, Jesse Garcia Castillo and Ahmed El-Hashash


Stem cells are known to have a paramount function in tissue regeneration and also the proliferation of cancer, and the ability that stem cells have to self renew allows them to differentiate and to regenerate injured tissues. More importantly, this capacity to self renew allows cancer stem cells to proliferate and promote cancer. Mesenchymal stem cells are multipotent cells that have the ability to differentiate into various cell types including; adipocytes, osteoblasts, and chondrocytes. These cells are known to regulate the healing of injuries and wounds and to activate cancer growth by secreting bioactive factors through paracrine signaling. Through scientific research, there is evidence that tissue specific and cancer stem cells also affect their surroundings through paracrine mechanisms, which would permit stem cells to facilitate wound recuperation and tumor proliferation, respectively. Because of this important connection, further investigation of the paracrine mechanisms by stem cells would ameliorate cancer treatment and cast light on the mechanisms of tissue regeneration.


Cancer, Stem Cells, Tissue Injury, Wound Healing.


Developmental Biology, Regenerative Medicine and Stem Cell Program, Saban Research Institute, Children`s Hospital Los Angeles, 4661 Sunset Boulevard MS 35, Los Angeles, California 90027, USA.