Developmental and Stem Cell Biology in Health and Disease

Research into stem cells started in the 1960s with experiments on spleen cultures. Evans and Kaufman made a breakthrough in mouse embryo culturing and embryonic stem cell extraction in 1981, followed ...
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Adult Stem Cell Niches and Their Regulatory Molecular Mechanisms

Pp. 106-120 (15)

John Ku, Wadah Alhassen, Haifen Huang, Salaheldin S. Soliman, Ahmed RN Ibrahim and Ahmed HK El-Hashash


The activation, survival, and quiescence of stem cells (SCs) are dependent on signaling within their niche or microenvironment. There are many types of SCs and SC niches that can be found in the human body. A single organ may contain more than one niche to accommodate for both slow and fast cycling SC populations. It appears that many SC niches possess similarities in both their cellular and molecular components. This chapter focuses on cellular organization, key molecular regulators, and the role of SC niches in aging and cancer.


Autocrine, apoptosis, blood, canonical, extrinsic factors, growth factors, hair follicle, hematopoietic, intrinsic factors, intestine, lineage, microenvironment, mesenchymal, mechanism, neuron, paracrine, quiescence, regulation, stem cell niche, stromal, transduction.


Developmental Biology, Regenerative Medicine and Stem Cell Program, Saban Research Institute, Childrens Hospital Los Angeles, 4661 Sunset Boulevard MS 35, Los Angeles, California 90027, USA.