Developmental and Stem Cell Biology in Health and Disease

Research into stem cells started in the 1960s with experiments on spleen cultures. Evans and Kaufman made a breakthrough in mouse embryo culturing and embryonic stem cell extraction in 1981, followed ...
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Gene and Signals Regulating Stem Cell Fates

Pp. 36-48 (13)

Mohamed Berika, John Ku, Haifen Huang and Ahmed El-Hashash


Recent developments have revealed more about the signaling pathways governing hematopoietic stem cell (HSC) fate; several developmentally conserved pathways were identified, including Notch, Smad pathways, Sonic hedgehog (Shh), and Wingless-type (Wnt). These findings contribute to our understanding of HSC regulation and provide information of interactions within the bone marrow environment where HSCs reside. The signaling pathways that contribute to HSC regulation are further discussed in this chapter.


Asymmetric divisions, Cell fate, Hematopoietic cells, Signaling pathway, Symmetric.


Developmental Biology, Regenerative Medicine and Stem Cell Program, Saban Research Institute, Childrens Hospital Los Angeles, 4661 Sunset Boulevard MS 35, Los Angeles, California 90027, USA.