Gene and Signals Regulating Stem Cell Fates
Pp. 36-48 (13)
Mohamed Berika, John Ku, Haifen Huang and Ahmed El-Hashash
Recent developments have revealed more about the signaling pathways
governing hematopoietic stem cell (HSC) fate; several developmentally conserved
pathways were identified, including Notch, Smad pathways, Sonic hedgehog (Shh), and
Wingless-type (Wnt). These findings contribute to our understanding of HSC
regulation and provide information of interactions within the bone marrow environment
where HSCs reside. The signaling pathways that contribute to HSC regulation are
further discussed in this chapter.
Asymmetric divisions, Cell fate, Hematopoietic cells, Signaling
Developmental Biology, Regenerative Medicine and Stem Cell Program, Saban Research Institute, Childrens Hospital Los Angeles, 4661 Sunset Boulevard MS 35, Los Angeles, California 90027, USA.