Phthalimide and hydrazine pharmacophores have been demonstrated to be inhibitors
of cyclooxygenases (COX) and lipoxygenases (LOX) and to possess a marked analgesic
and anti-inflammatory activity. A new group of hybrid analogs of phthalimide and
hydrazine (2-(arylmethylideneamino) isoindolines), possessing a variety of substituents
(OMe, OH, NO2, Cl, and F) at different positions of the aryl ring, were synthesized and
their analgesic and anti-inflammatory effects were evaluated. In vivo screening showed that
all the analogs possessed analgesic and anti-inflammatory activity and compounds 10g, 10h
and 10e were the most potent as analgesic and compounds 10b, 10c and 10i were the most
potent as anti-inflammatory agents.
Keywords: Analgesic, anti-inflammatory, hydrazone, isoindoline, phthalimide.
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