Evolving Novel Chemical Entities for Management of Benign Prostatic Hyperplasia#
V. L. Sharma.
Background: Proliferation of the smooth muscle and epithelial cells within the prostatic
transition zone in older men leads to benign prostatic hyperplasia (BPH), which is hallmarked by the
troublesome lower urinary tract symptoms. The affair responsible for the initiation and promotion of
disease is still unresolved, though alpha-blockers and 5α-reductase inhibitors are used as management
options for relief from the dynamic and static components respectively.
Method: Combination therapy including both the alpha blocker and 5α-reductase inhibitor is emerging as
inclusive parcel for treatment. However, selective androgen receptor modulators (SARM) and selective
estrogen receptor modulators (SERM) are the other management resources, which are in the limelight.
Result: This review gives a glimpse of BPH and the various chemical entities which have been
reported in literature till date for the condition since 2005.
Keywords: 5α-reductase inhibitors, alpha-blockers, benign prostatic hyperplasia, SARM, SERM.
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