In recent years, researchers like medicinal chemists in the field of medicinal
chemistry have widely utilized the 1,3,4-thiadiazole nucleus to investigate its biological and
pharmacological effects. This heterocyclic structure has demonstrated various bioactivities such
as antifungal, antimicrobial, antiviral, antileishmanial, anti-inflammatory, antihypertensive,
antiepileptic, and anticancer effects among others. Anticancer activity is one of its promising
effect as five membered heterocyclic rings have widely been investigated by researchers in the
recent years. Herein, we reviewed the chemical structures bearing 1,3,4-thiadiazole template
exerting anticancer activity.