A New and Convenient Synthesis of the Boceprevir P1 Fragment, β-amino-α-Hydroxy Amide

Author(s): Jayaprakash Rao Yerrabelly , Pradeep Rebelli , Bharathi Kumari Yalamanchili , Venkat Reddy Ghojala .

Journal Name: Letters in Organic Chemistry

Volume 13 , Issue 5 , 2016

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Abstract:

A new and convenient synthesis of the P1 fragment of HCV inhibitor, boceprevir is described. This approach efficiently provides P1 fragment of boceprevir using simple and easy handling reagents suitable for scale up. This synthetic route involves the conversion of ester intermediate into novel intermediate, α-chloro ketone via chloroacetate Claisen condensation, followed by further simple conversions to β-amino-α-hydroxy amide, P1 fragment of boceprevir in high yield.

Keywords: Boceprevir, Chloroacetate Claisen condensation, Convenient synthesis of boceprevir P1 fragment, P1 fragment, α-hydroxy amide.

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2016
Page: [352 - 358]
Pages: 7
DOI: 10.2174/1570178613666160628090059
Price: $58

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