Preliminary Experience with Yttrium-90-labelled Rituximab (Chimeric Anti CD-20 Antibody) in Patients with Relapsed and Refractory B Cell Non-Hodgkins Lymphoma

Author(s): Parul Thakral, Suhas Singla, Atul Vashist, Madhav P. Yadav, Santosh K. Gupta, Jaya S. Tyagi, Atul Sharma, Chandra S. Bal, Snehlata, Arun Malhotra.

Journal Name: Current Radiopharmaceuticals

Volume 9 , Issue 2 , 2016

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Abstract:

Background and Objectives: The aim of the study is to evaluate the therapeutic efficacy and safety of Yttrium- 90 radiolabelled chimeric anti CD20 antibody-Rituximab in the treatment of patients with relapsed/ refractory B cell Non-Hodgkins Lymphoma (NHL).

Methods: Twenty patients with relapsed/refractory CD20+ NHL in progressive state were included in the study. These patients had undergone a median of 2 (range 2-5) prior standard chemotherapy ± immunotherapy regimens. All the patients received rituximab 250 mg/m2 on days 1 and 8, and either 14 MBq/kg (0.4 mCi/kg) or 11 MBq/kg (0.3 mCi/kg) of Y-90 Rituximab on day 8 (maximum dose, 32 mCi) depending upon their platelet count. The patients were observed for systemic toxicity and response for at least 12 weeks after therapy.

Results: No acute adverse effects were observed after the administration of 90Y-Rituximab. Overall response rate (ORR) was 45% of which complete response (CR) was observed in 2 patients, stable disease in 1 patient and partial response in 6 patients. The therapy was well tolerated with grade IV thrombocytopenia, neutropenia and anemia observed in 3, 4 and 2 patients respectively.

Conclusion: 90Y-Rituximab therapy is safe and well tolerated in high risk extensively pretreated NHL patients. Toxicity is primarily hematologic, transient and reversible.

Keywords: FDG PET, mAb, NHL, Radioimmunotherapy, Rituximab, Yttrium-90.

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2016
Page: [160 - 168]
Pages: 9
DOI: 10.2174/1874471009999160625110400
Price: $58

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