Novel Palladium-Catalyzed Cascade Reaction of 2-Methylindoles with 2-Iodobenzyl Bromide Leading to Indole Fused Tricyclo[7,3,1,02,7]trideca-2(7),3,5-triene Ring System

Author(s): Edgars Abele, Sergey Belyakov, Tatjana Beresneva, Lena Golomba, Ramona Abele.

Journal Name: Current Organic Synthesis

Volume 13 , Issue 6 , 2016

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Abstract:

Novel palladium-catalyzed cascade reaction of 2-methylindoles with 2- iodobenzyl bromide in the system Pd(OAc)2 / Xantphos / t-BuOK / toluene leading to indole- fused tricyclo[7,3,1,02,7] trideca-2(7),3,5-triene ring system was presented. Palladium catalyzed reaction of 2-methylindoles with 6-bromo-5-bromomethylbenzo[1,3] dioxole leads to 3,3-bis(6-bromobenzo[1,3]dioxol-5-ylmethyl)-2-methyl-3H-indoles.

Keywords: Palladium catalysis, 2-methylindoles, potassium t-butoxide, 2-iodobenzyl bromide, tricyclo[7, 3, 1, 02, 7]trideca-2(7), 3, 5-trienes.

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2016
Page: [883 - 887]
Pages: 5
DOI: 10.2174/1570179413666160624095554
Price: $58

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