Synthesis and Quantum Chemical Studies on the Tautomeric Structures of New Thiazole and Thiadiazine Derivatives

Author(s): Sobhi M. Gomha , Fatma A. A. El-Hag , Ahmed M. El Defrawy , Thoraya A. Farghaly .

Journal Name: Current Organic Synthesis

Volume 13 , Issue 6 , 2016

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Abstract:

New series of thiazoles and thiadiazines incorporated with pyrazole ring were synthesized via the reaction of 2-(1-(4-cyano-1,5-diphenyl-1H-pyrazol-3-yl)ethylidene) hydrazine-carbothioamide or 4-imino-7-methyl- 2,3-diphenyl-2H-pyrazolo[3,4-d]pyridazine-5(4H)-carbothiohydrazide with different reagents. The structures of all tautomeric forms of the newly synthesized compounds were confirmed on the basis of spectral data aided with DFT and semi-empirical calculations.

Keywords: Thiazoles, thiadiazines, tautomeric structure, DFT.

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2016
Page: [907 - 916]
Pages: 10
DOI: 10.2174/1570179413666160624093735
Price: $58

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