Rhein is one of the main components of Rheum. It is widely used for the treatment of tumor, virus,
diabetic nephropathy, bacterial infection and inflammatory, and it shows excellent clinical application value.
Here, recent studies on the pharmacological activity and synthesis of rhein and its derivatives were reviewed
and future direction was also briefly discussed, hoping to provide beneficial information for the research of
rhein and its derivatives.
Keywords: Derivative, pharmacological activity, rhein, structure modification, synthesis.
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