5-Alkylidenethiophen-2(5H)-ones as Biofilm Inhibitors

Author(s): Tore Benneche, Elahe Jafari Chamgordani, Gunnar Herstad, Bjørg Siw Møller Tannæs, Anne Aamdal Scheie.

Journal Name: Letters in Organic Chemistry

Volume 13 , Issue 6 , 2016

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Abstract:

A number of thiophen-2(5H)-ones with different substituents in the 3-, 4- and 5-position have been synthesized and tested as inhibitors of biofilm production by the marine bacterium Vibrio harveyi BB120. Concentrations that inhibited 50% or 90% of biofilm formation (BIC50, BIC90) and of plantonic growth (PIC50, PIC90) are reported.

Keywords: 5-alkylidenethiophen-2(5H)-ones, biofilm inhibition, quorum sensing, synthesis.

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2016
Page: [428 - 436]
Pages: 9
DOI: 10.2174/1570178613666160620114658
Price: $58

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