In the last decade, several radiolabeled compounds have been developed for the imaging in
vivo of amyloid pathology by means of Positron Emission Tomography (PET). Among these, 18F
Florbetaben appear to be one of the most reliable for its high affinity for amyloid plaques in brain and
its radio-chemical properties that make it usable in common clinical routine.
The aim of this review is to provide a general overview of the application in vivo of 18F Florbetaben,
describing for first the physiopathological basis of amyloid pathology. Afterwards, the chemical
characteristics of this radiolabeled compound will be described, with a particular attention to the synthesis
process and the kinetic in vivo. An overview on the imaging protocols and image interpretation
will be provided as well and, as a last aspect, the results of the main studies performed in subjects
with advanced and early AD will be summarized.